school
Macau Periodical Index (澳門期刊論文索引)
- Author
- Chu, Man; Wong, Chun Kwok; Tam, Lai Shan; Lam, Wai Kei
- Title
- Cytokine and Chemokine aberrations in systemic lupus erythematosus
- Journal Name
- 澳門科技大學學報
- Pub. Info
- Jun. 2014, Vol.8, No.1, pp. 108-115
- Link
- http://lib.must.edu.mo/sites/default/files/assets/images/Duu/must_journal_201401.pdf
- Keyword
- SLE；Th1/Th2 cytokines；Chemokines
- Abstract
- Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects adult women. Although the underlying causes and pathological mechanisms have not been clearly elucidated, it is known that cytokine and chemokine aberrations, as well as genetic, hormonal and environmental factors, are intricately involved in the initiation and development of SLE. Aberration of cytokines and chemokines resulting in dysregulation of different immune cell subsets, such as T helper (Th) 1/Th2 and Th17/regulator T(Treg) lymphocytes contributing to the pathogenesis of SLE will be discussed in this review. Paragraph headings: 1. Background 2. Underlying causes and pathological mechanisms of SLE 3. Pathological roles of cytokines and chemokines in SLE 3.1. Imbalance of Th1/Th2 cytokines in SLE 3.2. Imbalance of novel Th17/Treg cytokines in SLE 3.3. The role of chemokines contributing to SLE 4. Summary Tables: 1. American college of Rheumatology Criteria for the Diagnosis of Systemic Lupus Erythematosus (SLE) 2. The major cytokines produced by Th1 and Th2 cells Figures: 1. Effector T cell differentiation (Th1, Th2, Th17 and Treg), effector cytokines, chemokine receptors, and T-cell functions.