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Macau Periodical Index (澳門期刊論文索引)
- Author
- Zhou, Ye; Le, Yingying; Iribarren, Poblo; Gong, Wanghua; Zhang, Xia; Wang, Ji Ming
- Title
- The Role of Chemokine Receptors CCR5 and CXCR4 in HIV-1 Infection
- Journal Name
- 澳門醫學雜誌
- Pub. Info
- 2004年3月26日, Vol.4, No.1, pp. 17-21
- Keyword
- HIV；Coreceptor；Chemokine,ADIS
- Abstract
- Abstract : Chemokines are key mediators of a variety of pathophysiological responses, including leukocyte trafficking, lymphoid tissue organogenesis, inflammation, allergy, atherosclerosis and malignanacy. Chemokines bind and activate a group of G protein-coupled receptors, which,upon ligand binding, transmit a cascade of signaling events culminating in cell migration and activation. For the past few years, chemokine and their receptors have received particular attention due to the discoveries that some of the chemokine receptors are utilized by human immunodeficiency virus type 1(HIV-1) as coreccptors for cellular entry. Although a number of chemokine and orphan receptors for T-cell line tropic(X4) and macrophage tropic (R5) viruses, respectively. Consequently, chemokine ligands for CXCR4 or CCR5 are potent host-derived anti-HIV-1 agents based on their competitive receptor binding activity and down-regulation of the viral coreceptors. It is recognized that agents targeting HIV-1 coreceptors may have important theraoeutic potential. Paragraph Headings： 1. Intriduction 2. Major HIV-1 coreceptors CCR5 and CXCR4 3. Chemokine receptors in HIV-1 entry 4. Chemokine receptors in HIV-1 resistance and progression 5. Chemokine receptors as therapeutic targets 6. Coreceptor antibodies and modified chemokines 7. Small peptide antagonists 8. Low molecular weight compounds 9. Conclusion 10. Acknowledgements Figures： 1. Chemokine receptor-dependent cell tropism of HIV-1. TCL-tropic HIV-1 infects CD 4*T cell lines and primary Tcells by using CXCR4. M-tropic HIV-1 infects macrophages and primary T cells through CD4 and CCR5. Dual-tropic HIV-1 uses both CXCR4 and CCR5 to infect CD4*T cell lines, primary T cells and macrophages.