school
Macau Periodical Index (澳門期刊論文索引)
- Author
- Cha, Cai-hui; Xiao, Ji-hua
- Title
- Clinical application and advancement of risperidone
- Journal Name
- 澳門醫學雜誌
- Pub. Info
- 2001年12月31日, Vol.1, No.4, pp. 253-256
- Keyword
- Risperidone；Schizophrenia
- Abstract
- Abstract : Objective :This article reviews the mechanism, pharmcokinetics and the clinical use of risperidone. Materials : The data base on updated literature recently. Conclusion : Risperidone, a benzisoxazol derivative, is a novel typical antipsycotic agent which combines 5-hydroxytryptamine-2 (5-HT2)and dopamine-2 (D2) receptors antagonism. It can improve both positive and negative symptoms of schizophrenia. The efficacy of risperidone is well positive and effective in patients with chronic schizophrenia who had been resistant to or intolerant of conventiona brain injury associated behavioral and psychiatric disorder and now it is already used in clinic widely. Risperidone is absorbed rapidly when taken orally and mainly metabolized in the liver. The principal active metabolite is mainly discharged via urine. Risperidone has high efficacy and good safety. Now it is already used in clinic widely. Paragraph Headings： 1. Introduction 2. Mechanism of action 3. Application in clinic 3.1. Treatment for schizophrenia 3.2. Treatment for the other psychotic disorders 4. Adverse Reactions 5. Conclusions