Human trafficking is one type of transnational organized crime issue nowadays, because base on the nature of human trafficking it cannot respond it alone by the effort of one state. In case of Association of Southeast Asian Nations (ASEAN) is a political and economic organisation of ten member states in Southeast Asian. It was established in 8 August 1967 by five member states first as Indonesia, Malaysia, the Philippines, Singapore, and Thailand. After that the other states in Southeast Asian had joined in as followed: Brunei Darussalam, Vietnam, Laos and Myanmar and Cambodia. Nowadays, international or regional inter-governmental organizations are also collective to respond and combat different kinds of transnational organized crime such as drug trafficking or human trafficking. In generally, ASEAN is focus on dealing with regional integration relevant with economic cooperation and overlook the problem of human trafficking. This article will attempt to explore collective response to human trafficking issue in ASEAN and identify current regional governance situation in human trafficking in ASEAN. Besides, theory of Neoliberal Institutionalism will be used to identify the mechanism and institution of combating human trafficking in ASEAN at international and regional level currently. Base on these factors how to made ASEAN member states collective cooperation and effectively combating human trafficking in international, regional and domestic level. Base on the analysis of theory of Neoliberal Institutionalism, improvements and recommendations will be explored for ASEAN. Moreover, throughout the analysis and study of human trafficking issue, the current dynamic operation from regional to international cooperation in transnational organized crime matters can also be thoroughly recognized.