This study aimed to determine the relationships between three major organizational barriers (leader-member exchange, perceived organizational support, and emotional exhaustion) and four variables (job satisfaction, organizational commitment, turnover intention, and perceived service quality) from the perspectives of frontline employees in the Convention and Exhibition (C&E) industry in Macau. The ultimate goal was set to examine whether the three organizational barriers would affect service quality that frontline employees would provide. In contrast to previous studies that concentrated on human resources issues or economic issues, this study focused on organizational issues especially for employees who worked frontline in the C&E market, and investigated reasons for change in employees’ working attitudes and performances. Data collected from in-depth interviews and survey questionnaires, this study revealed that perceived organizational support (POS) contributed strongly and significantly to all independent variables (job satisfaction, organizational commitment, turnover intention, and perceived service quality). Job satisfaction was proven to be a mediator between leader-member exchange (LMX) and turnover intention of frontline employees in the C&E industry. Job satisfaction also mediated emotional exhaustion (EE) and perceived service quality in this study. According to the results, POS was the strongest factor which influenced employees’ job attitudes and service quality provided. The findings of this study showed that POS was an important element to make improvement within the organization, as it affected employees’ attitudes to work and job performances. Therefore, this study suggested that C&E organizations should increase the level of support to frontline employees at work. At the same time, acknowledge and recognize employees’ contributions and efforts.