Normobaric hypoxia training as a potential method which came from the athletes` altitude training has been gradually applied to the weight control in recent years.Using a quasi-experimental design of between-groups and within-subjects, the purpose of this research was to investigate the effect of the vascular function during weight loss under normobaric hypoxia environment. 22 overweight adults (10 males, 12 females), (age 21.3 ± 3.6 years, BMI > 28.5kg/m2 ) were recruited publicly for a period of 4 weeks of normobaric hypoxia training (HT, 5 males, 5 females) with moderate altitude exposure (2000-3000m) or normoxia training (NT, 5 males, 7 females) groups. Weight, body composition, blood pressure (BP), the pulse wave velocity and ankle-brachial pressure index (PWV/ABI) and some blood clinical parameters of atherosclerosis were used to evaluate the effect of vascular functions during weight loss. Significant weight losses were found in both groups ( p < 0.001), with group NT reducing by 4.33 kg (4.2%) and group HT reducing by 6.92 kg (7.0%), and weight loss in HT was significant more than in NT (p < 0.01). Regarding the factors on atherosclerosis, a trend to decrease was found in BP and PWV, and a trend to increase was found in ABI. For blood clinical parameters, no significant effect of between-groups but within-subjects was found. The levels of prostaglandin E2 (PGE2), atrial natriuretic peotide (ANP) and angiotensin-I (ANG-I) decreased significantly with range of 31.7 - 33.3 % in NT group and 23.3 - 28.9% in HT group, while the decrease of PGE2 in NT had a sinnificant trend to be more than that in HT (p = 0.09). The concentrations of Endothelin-1 (ET-1) increased significantly by 188.1 % in NT and 253.9 % in HT group. In conclusion, both of the two programs for 4 weeks of exercise and diet control intervention could loss weight significantly while normobaric hypoxia training with moderate altitude exposure led to more weight loss than normoxia training in obese youths. Addtionally, the two weight loss programs had positive effect on vascular function while normobaric hypoxia exposure instead of nomoxia training for 24 hours had no more advantages in vascular function.

肥胖作為一種慢性疾病為人們所關注，有研究表明低氧運動可以更加有效 降低體重，不過相關研究尚不多見。本文採用組內（時間）和組間（氧濃度） 準實驗法設計，通過低氧減肥過程中血管系統指標監測，意在闡明低氧運動對 肥胖青少年血管功能的影響。 將募集有志減肥的青少年 22 人（年齡 21.3 ± 3.6 years，BMI > 28.5 kg·m-2） ，隨機分為低氧訓練組（HT，5 男，5 女）和常氧訓練組（NT，5 男， 7 女），所有受試者均來自平原地區，且之前均未接受過低氧訓練。訓練計畫持 續 4 週，常氧訓練組接受每週 11、次每次持續 2 小時的運動訓練，低氧訓練組 除常氧訓練外，還接受每週 3 次、每次 2 小時的中等高度低氧環境下的訓練 （2000-3000 m），低氧訓練組運動總時間與常氧訓練組相同。根據基礎代謝的 情況，兩組受試者均給予相當於 75%基礎代謝的膳食攝入。訓練前後分別採集 受試者身體成分、基礎血壓、心率、動脈硬化指標及反應血管機能的血液指標。 結果發現：與訓練前相比，兩組降體重均有顯著性降低（p < .001），NT 組 體重降低 4.33 kg（4.2%），HT 組體重降低 6.92 kg（7.0%），體重降低 HT 顯著 多於 NT 組（p < .01）。HT 組收縮壓（SBP）顯著降低（-8.1%，p < .05），舒張 壓（DBP）有下降趨勢（-6.4%，p = .10），NT 組無顯著改變；踝臂脈搏波傳導 速度（PWV）僅在 NT 組右側有降低趨勢（p = .09），踝臂指數（ABI）在 NT 組有下降趨勢（p = .06）；在血液內分泌指標方面，前列腺素 E2（PGE2）、心鈉 素（ANP）及血管緊張素Ⅰ（ANG-I）在組內顯著降低（p < 0.01），降低範圍 HT 組為 23.3 – 28.9%，NT 組為 31.7 – 33.3%，而血管內皮素-1（ET-1）組內顯 著升高（p < 0.01），HT 組升高 253.9%，NT 組升高 188.1%；此四種荷爾蒙指標 組間變化無顯著性差異，但 NT 組 PGE2 的降低有顯著多於 HT 組的趨勢（p = .09）。 結果表明，輔助於低能量攝入的 4 週低氧訓練及常氧訓練均能顯著降低肥 胖人群體重，且低氧降體重效果比單純常氧效果好；4 週兩種模式訓練對血管內 分泌方面都有良好作用；低氧訓練並不能引起血管機能更顯著的改變。 關鍵字：肥胖；飲食控制；常壓低氧訓練；減重；血管機能