The main purpose of this study was to examine the relationship among stress, live-up-to parental expectations, and psychological adjustment (including depression and anxiety) of college students in Macau. Meanwhile, live-up-to parental expectations were applied as the moderators to analyze the interaction between life stressors, live-up-to parental expectations, depression and anxiety. Self-reported questionnaires were used as instruments in this study included ICSRLE, LPEI, FNE translated and CES-D translated. Year one to year four local students under the Bachelor’s Degree Program at the University of Macau were invited to participate in this study. Results of this study indicated that the more overall life stressors college students had, the higher level of depression and higher level of anxiety they would experience; the bigger range of difference in overall live-up-to parental expectations college students had, the more overall life stressors they had; the bigger range of difference in overall live-up-to parental expectations college students had, the higher level of depression and higher level of anxiety they would experience. However, live-up-to parental expectations did not appear to have any moderating effect between the relationship of life stressors and psychological adjustments (including depression and anxiety). Keywords: Life Stressors, Live-up-to Parental Expectations, Psychological Adjustment, Depression, Anxiety

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