Flexible tactile sensors have attracted considerable interests because of their potential applications in healthcare monitoring, human-machine interaction, information communication, etc. Although extensive materials and microstructures have been studied to develop high-performance sensors, the simultaneous optimization on sensitivity and linearity, the critical parameters of flexible tactile sensors, is yet to be resolved. Moreover, the facile fabrication of precise microstructures instead of sophisticated and expensive processes is also challenging to facilitate practical applications. In this thesis, several design strategies aiming to simultaneously optimize the sensitivity and linearity via facile and cost-effective methodologies were studied and discussed. First of all, a AgNWs-coated hybrid structure comprised of meso-scaled dome and micro-scaled pillar arrays was developed for piezoresistive tactile sensors. The hybrid architecture could be conveniently acquired via applying vacuum in spin-coating process, and rendered the dramatically improved sensitivity of 128.29 kPa-1 (0-200 Pa). To simultaneously optimize the sensitivity and linearity, a novel CPDMS/AgNWs double conductive layer was further designed. The derived pass-through resistance could broaden the resistance variation range and balance the non-linear contact resistance variation. Assisted by interlocked porous micro-dome arrays, the ultrahigh sensitivity (924.37 kPa-1) and wide linearity range (0-70 kPa) was simultaneously realized, which is rarely reported. Furthermore, to simultaneously optimize the sensitivity and linearity of capacitive tactile sensors, a novel hybrid dielectric composed of a low-k micro-cilia array, a high- k rough surface and micro-dome array was designed. The gradient compressibility and pressure-induced series-parallel conversion derived the linear elastic modulus and dielectric behavior, facilitating a high sensitivity of 0.314 kPa-1 in an ultrawide linearity range (0-1000 kPa), which is first reported. The design also realized the similar linear voltage output and enhanced sensitivity of triboelectric tactile sensor. To fulfill the facile fabrication, a gradient micro-dome architecture-based dielectric was finally designed. The gradient micro-dome pixels with rationally collocated amount and height derived the linear dielectric behavior, thus enabling an ultrabroad linearity range (0-1700 kPa) with a high sensitivity of 0.065 kPa-1 of the sensor, which is also first reported. These designs can provide promising strategies for the development of high-performance wearable sensors towards diverse applications in the future.