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Macau Periodical Index (澳門期刊論文索引)
- Author
- 何雅明；劉寧；佘穎琪；⽂怡；吳建煒
- Title
- Exploring the potential causal impact of dietary factors on prostate cancer risk: a two-sample mendelian randomization study
- Journal Name
- 澳門護理雜誌
- Pub. Info
- 2025年10月, 第24卷第1期, pp. 43-114
- Link
- https://www.kwnc.edu.mo/Journal/FullText/MJN_2025%20Vol.25%20No.01/[P.43-114]06_MJN_2025_Vol.24_No.01.pdf
- Keyword
- Dietary factors；Prostate cancer；Causal relationship；Mendelian randomization
- Abstract
- Objective: Conventional observational research has indicated a link between dietary factors and prostate cancer (PCa), yet the impact ofconfounding factors on this association remains uncertain. The aim of this study was to investigate the potential causal relationship between dietary factors and PCa using the Mendelian randomization (MR) approach. Methods: We examined the potential causal association between dietary factors and PCa by employing a two-sample MR approach. In this study, summary statistics from genome-wide association studies (GWAS) on dietary factors and PCa were extracted from the UK Biobank and FinnGen databases. Six different MR analysis methods were employed to explore the correlation between dietary factors and PCa. The main analytical method is the inverse variance weighted (IVW) method. Meanwhile, we used MREgger regression, Cochran's Q test, the MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test, and the leave-one-out method to assess the robustness of the MR results. Results: The results of this study showed that the average weekly beer plus cider intake (OR=3.305, p=0.040) and oily fish intake (OR=1.877, p=0.012) were correlated with an increased likelihood of developing PCa, while green tea intake was negatively associated with the risk of PCa (OR=0.985, p=0.014). There was no significant direct causal relationship between other dietary factors and PCa in this study. Conclusion: This study found that increasing the average weekly beer plus cider intake and oily fish intake may increase the risk of PCa, while increasing green tea intake may reduce the risk of PCa. The results of this study can provide a reference for optimizing dietary intervention measures in the fields of public health and nursing and assist in the prevention of PCa. Paragraph Headings： 1. Introduction 2. Materials and methods 2.1. Study design 2.2. Data sources 2.3. Selection of IVs 2.4. Statistical analysis 2.4.1. MR analysis 2.4.2. Heterogeneity, horizontal pleiotropy, and sensitivity analysis 2.4.3. Statistical power calculation 3. Result 3.1. MR results presentation 3.2. Selection of IVs 3.3. Causal estimates of genetic susceptibility to dietary factors and PCa risk 4. Discussion 4.1. Average weekly beer plus cider intake and PCa 4.2. Oil fish intake and PCa 4.3. Green tea intake and PCa 4.4. Other dietary factors and PCa 4.5. Implications for nursing practice and nursing research 4.6. Advantages and limitations 5. Conclusion Tables： 1. Information of the 22 kinds of dietary factors and PCa Figures： 1. The flow chart of this study design 2. MR requires three key assumptions for instrumental variables 3. MR analysis results of the causal relationship between dietary factors and PCa