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Macau Periodical Index (澳門期刊論文索引)
- Author
- Pun, Man Ieng; Ip, Kar Hung
- Title
- The antineutrophil cytoplasmic antibody: associated vasculitis
- Journal Name
- 澳門醫學雜誌
- Pub. Info
- 2008年9月26日, Vol.8, No.3, pp. 258-261
- Link
- https://www.ssm.gov.mo/docs//2206/2206_9300d487829043bb9e1edf55ef000249_000.pdf
- Keyword
- Wegener's granulomatosis；Microscopic Polyangiitis；Churg-Strauss syndrome；Proteinase；Myoperoxidase
- Abstract
- Abstract : The primary systemic small vessel vasculitides include Wegener's granulomatosis (WG), Churg-Strauss syndrome (CSS), microscopic polyangiitis (MPA) and its renal limited form (idiopathic necrotizing and crescentic glomerulonephritis). These conditions also are referred to by some investigators as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). This term emphasizes the similarities between these conditions, including the predominant size of vessel involved, renal histology, and association with ANCA. Whereas the majority of patients with Wegener's granulomatosis have ANCA directed to proteinase 3 (PR3–ANCA), most patients with MPA and idiopathic necrotizing and crescentic glomerulonephritis display antibodies to myeloperoxidase (MPO–ANCA). In contrast, only approximately 35%–50% of patients with Churg–Strauss syndrome are positive for ANCA, in most cases MPO–ANCA. Paragraph Headings: 1. Case report 2. Intorduction 3. ANCA and ASV (Systemic Vasculitides) – clinical aspects 4. Pathogenesis 5. Recent therapeutic developments in ancaassociated vasculitides 6. Cyclophosphamide or azathioprine for maintenance of remission 7. Plasmapheresis for lifethreatening cases of ancassociated vasculitides 8. Induction of remission in ANCA-associated vasculitides 9. Conclusions