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Macau Periodical Index (澳門期刊論文索引)
- Author
- Luo, Yi-long; Wu, Wei; Zhang, De-hong
- Title
- Prevalence of metanolic syndrome in Macao patients with obstrutive sleep apnea
- Journal Name
- 澳門醫學雜誌
- Pub. Info
- 2008年6月26日, Vol.8, No.2, pp. 115-121
- Link
- https://www.ssm.gov.mo/docs//2205/2205_4564a1ad029346bfabb627a1ec3f20cd_000.pdf
- Keyword
- Hypertension；Metabolic syndrome；Obesity；Obstructive sleep apnea；Prevalence
- Abstract
- Objective: Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) represent significant risk factors for the development of cardiovascular disease. The purpose of this study was to determine the prevalence of MetS and its individual components in Macao patients with OSA and to assess association of MetS with the severity of OSA. Methods: In a case-control study of Macao patients with OSA, we recruited participants from 523 consecutive patients referred to the sleep clinic of Centro Hospitalar Conde de São Januário, Macao, China, for the evaluation of OSA between Jan, 2002 and Dec, 2007. All the participants did polysomnography and essential laboratory examination. OSA was diagnosed using American Academy of Sleep Medicine criteria and MetS was defined according to Chinese Medical Association criteria. We assessed the prevalence of MetS and its components at different severity of OSA. Logistic regression model was established to assess the effect of AHI on the risk for metabolic syndrome in patients with OSA. Results: A total of 421 adults were enrolled in our study. Among them, 314 patients has OSA, whereas 107 individuals having an AHI of <5/h. The proportion with hypertension (56.4% vs 48.6%, p<0.05) and overweight (78.7% vs 58.9%, p<0.01) was significantly higher in the OSA group than that of the controls. The prevalence of the MetS in controls, patients with mild, moderate and severe OSA were 31.8%, 36.5%, 42.6%, and 44.7% respectively (p<0.05). The severity of OSA is independently associated with MetS, overweight and hypertension (p<0.05). In a stepwise regression model, significant predictors of MetS in patients with OSA included AHI, age and female gender (p<0.05). Conclusions: Overweight and hypertension was more common in patients with OSA than those without OSA. The prevalence of MetS, overweight and hypertension increases significantly with increasing severity of OSA. In patients with OSA, age, sex, and AHI are significant predictors for the presence of MetS. Physicians should recognize MetS as a frequent comorbidity of OSA and treat it to prevent serious complications. Paragraph Headings: 1. Methods 1.1. Study Population 1.2. Assessment of MetS 1.3. Polysomnography 1.4. Statistical Analysis 2. Results 3. Discussion 4. Conclusion Tables: 1. Patient Characteristics between OSA group and the control group 2. Prevalence of MetS and its Components in 421 Consecutive Patients 3. Prevalence of MetS and its Components According to the Severity of OSA