Macau Periodical Index (澳門期刊論文索引)

Koon, Kin Veng; Lam, Cheok Meng; Lei, Chi Hang
Pathogen occurrence and antimicroial susceptibility patterns among urinary tract infection isolates of Macau adult patients
Journal Name
Pub. Info
2003年9月26日, Vol.3, No.3, pp. 149-151
Urinary tract infection(UTI);Pathogen;Susceptibility
Objective: To determine causative pathogens of urinary tract infections in macau adults and obtain data on susceptibility patterns among them for direct empirical therapy against currently used antimicrobial agents. Method: During the period from January to June 2002, midstream freshly voided urines from = 20 years old Macau adults were cultivated with Uriline media; pure/duplicated isolates, = 10 5 CFU/ ml in CLED side media were accounted. Bacterial identification and antimicrobial sensitivity test were analysed by "Vitek automatic card system". Seven antibacterials, Amoxicillin/clavulanic acid, Ampicillin, Ceftriaxone, Ciprofloxacin, Gentamicin, Nitrofurantoin and Trimethoprim/sulfamethoxazole were chosen to test in this study. Result: A total of 2972 urine specimens were collected. Except contamination, 400 cases were culture positive and 414 organisms were isolated. The isolation rate was 13.5% Escherichia coli was the predominant uropathogen in all categories, the other important pathogens followed by Klebsiella pneumoniae, Pseudomonas spp. and other species in a lower frequency. In general, resistances to antimicrobials tested were common. The best choices against E. coli isolates were FUR and, against K. pneumoniae was, and against Pseudomonas spp. was CIP, constituted reasonable therapeutic options. Conclusion: Considering more common bacteria in UTI and more effective drugs with respect to the data mentione, FUR and CRO were recommended for empirical and more effective drugs with respect to the data mentioned, FUR and CRO were recommended for empirical treatment of UTIs in Macau adults, whiles CIP was needed for suspected Pseudomonas spp. pathogens. But regimen must consider reasonable antibiotic administration rules, as high efficacy, costs less and causes fewer side effects. And decisions to treat orally or parenterally should be individualized based upon age, vomiting, reliability of follow-up, and drug toxict, etc. Paragraph Headings: 1. Introduction 2. Objective and methods 3. Results 4. Discussion and conclusion Tables: 1. Distribution of positive specimen in test requesting institutes 2. Sex distribution of UTI patients 3. Species distributioin of UTI isolates 4. Susceptibility of bacteria isolated from UTIs to various antimicrobials 5. Susceptibility of the first three prevalent bacteria isolated from hospital and community UTIs