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Macau Periodical Index (澳門期刊論文索引)
- Author
- Chen, Ximing
- Title
- Inlfuence of succinylcholine on the dose-response relationship of subsequently administered recuronium
- Journal Name
- 澳門醫學雜誌
- Pub. Info
- 2004年12月26日, Vol.4, No.4, pp. 240-243
- Keyword
- Rocuronium；Succinylcholine；Dose-response relationship；Drug interaction
- Abstract
- Objective：To study the effects of succinylcholine on the dose-response relationship of subsequenctly administered rocuronium in healthy patients. Method：Forty-eight ASA physical status I-II patients, aged 17-65 years, scheduled for elective general surgery, patients were randomly assigned to either the rocuronium treatment group(R) or succinylcholine-rocuronium treatment group (SR). Gerenal anesthesia was induced with thiopental 4 to 6 mg/kg and fentanyl 2 to 5 μg/kg intravenously and maintained with 60% nitrous oxide in oxygen. Additional doses of thiopental or fentanyl were administered as required. The dose-rsponse relationahip of rocuronium was determined by the single dose-response technique. In R group (n=24), rocuronium was given after induction of anesthesia. In SR group (n=24), patients were intubated after 1.5 mg/kg of succinylcholine and rocuronium was given after the complete recovery of neuromuscular blockade from succinylcholine. Patients were further randomly divided into 4 subgroups receiving 150,200,250 or 300 μg/kg of rocuronium respectively in both groups. Neuromuscular function was assessed accelographically with train-of-four (TOF) stimulation at the wrist every 12 seconds (using the TOF Guard® accelerometer). The relationship between probit-tranformed percentage depression of first twitch height (Th) of train-of-four stimulation and logarithm dose of rocuronium was analyzed using linear regression. Result：The dose-response curve of rocuronium after succinylcholine was shifted to the left in a parallel fashion compared with that of rocuronium given alone. ED50 and ED95 of rocuronium were 193 ± 69 and 367 ± 73 μg/kg respectively in R group, and 158 ± 35 and 317 ± 80μg/kg respectively in SR group (p<0.05). Conclusion：Succinylcholine shifts the dose-response curve of rocuronium to the left and potentiates the effects of the neuromuscular blockade by about 15% of subsequently administered rocuronium. Lower doses of rocuronium are required after prior succinylcholine. Paragraph Headings： 1. Introduction 2. Materials and methods 2.1. Patients and groups 2.2. Anesthesia 2.3. Measurements of neuromuscular function and statistical analysis 3. Results 4. Discussion Tables： 1. Demographic data 2. Dose-response data of rocuronium after and without succinylcholine