school
Macau Periodical Index (澳門期刊論文索引)
- Author
- Wong, Keong; Leong, MW; Lam, YH
- Title
- Estimated 2nd trimester maternal serum markers AFP &HCG moms for down's syndrome screening in Macao
- Journal Name
- 澳門醫學雜誌
- Pub. Info
- 2001年4月2日, Vol.1, No.1, pp. 11-14
- Keyword
- Downis syndrome；Screening；Second trimester
- Abstract
- Objective: Offered second-trimester serum AFP and hCG screening study to pregnant women younger than 35 years should be offered maternal serum screening at 16 to 18 weeks of gestation and without other risk factors for chromosomal abnormalities. Materials: Between August 1998 and January 2001, we each woman was assigned a risk of having a Downis syndrome tern pregnancy by using a computer software program that took into account her age, weight, AFP and hCG Moms. All those with a risk of one in 250 or greater were designated screen-positive, subject to the revision of gestation by ultrasound examination. Results: After revision of the gestation by ultrasound examination, 89 of them (97 per cent) accepted the offer of amniocentesis. Downis syndrome and all the women elected pregnancy termination affected two of these pregnancies. The odds of being affected, given a positive screening result, were one in 17. The screening programmed missed one Downis syndrome pregnancy. The detection rate was 60 per cent. Conclusion: The study showed that second-trimester serum screening for fetal Downis syndrome was feasible and acceptable in the Macao Chinese population. Tables: 1. Median calculation for serum AFP(regressed) 2. Median calculation for serum hCG