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Macau Periodical Index (澳門期刊論文索引)
- Author
- Wang, Danbo; Zhang, Shulan; Meng, Lirong; Niu, Huiyan
- Title
- Relation of CDKN2, nm23 gene products expression with biologic behavior of ovarian epithelial tumor
- Journal Name
- 澳門醫學雜誌
- Pub. Info
- 2003年6月26日, Vol.3, No.2, pp. 71-73
- Keyword
- Ovarian tumor；Immunohistochemistry；p16 protein；nm23 gene
- Abstract
- Objective: Our purpose was to study the expression of p16 protein and NDPK/nm23 in ovarian epithelial tumor. Methods: Compared with normal ovary, the expression of p16 protein and NDPK/nm23 was observed immunohistochemically on formalin-fixed paraffin embedded sections in 37 cases of ovarian benign tumor, 33 cases of ovarian borderline tumor and 69 cases of ovarian epithelial carcinoma. Results: The positive rate of p16 protein was lower and that of NDPK/nm23 was higher in ovarian carcinoma. The present of p16protein was not related at histological types of tumor. The mucous carcinoma differed significantly from serous and endometrioid carcinoma in positive rate of NDPK/nm23 was not related of differentiation of the tumor. The positive rate of both gene products were higher in stage to carcinoma than in stage t ocarcinoma. Conclusion: Inactivation of tumor suppressor gene CDKN2 that leads to deletion of p16 with the genesis and less with the progression of ovarian carcinoma. Paragraph Headings： 1. Materials and method 1.1. Samples 1.2. Immunohistochemisty 1.3. Statistical analysis 2. Results 2.1. The expression of p16 protein and NDPK/nm23 in ovarian epithelial tumor 2.2. The relation of p16 protein, NDPD/nm23 expression with histological type and pathologic grading 2.3. The relation of p16 protein, NDPK/nm23 expression with the staging of ovarian carcinoma 3. Discussion Tables： 1. The expressin of p16 protein and NDPK/nm23 2. The relation between the expression of p16 and NDPK/nm23, histological type, and pathologic grading 3. The relation of p16 protein, NDPK/nm23 expression with the staging of ovarian carcinoma